The cause of ALS is unknown. Many factors can be involved in whether someone develops her ALS. These include genetics, gender, race, exposure to toxins, and other environmental factors.
Amyotrophic lateral sclerosis (ALS) is a neurological disease that affects motor neurons (nerve cells that control muscle movement and breathing).
In ALS, motor neurons stop functioning and begin to die. This leads to muscle weakness, loss, and eventually paralysis.
The exact cause of ALS is still unknown. However, scientists have identified several potential risk factors.
Expert estimates
Scientists have identified several genetic mutations that contribute to ALS. These include mutations in the following genes:
The ALS Association notes that mutations in these genes are found in up to 70% of familial ALS diagnoses.
Genes associated with ALS are usually associated with familial inheritance. However, patients with sporadic (non-familial) ALS may carry genetic mutations caused by environmental damage.
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However, a 2024 review notes that this evens out with age, with ALS prevalence in older women similar to men.
ALS can affect people of all races and ethnicities. However, it is much more common in Caucasians.
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Smoking has several negative effects on the body. Studies have also linked it to an increased risk of ALS.
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Research has identified military service as a potential risk factor for ALS.
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Studies have linked exposure to various environmental toxins to ALS risk. for example,
- Heavy metals such as lead, mercury, and selenium
- Pesticides, including herbicides and insecticides
- solvent
A 2022 review also found that exposure to beta-N-methylamino-L-alanine (BMAA), a non-protein amino acid made by certain types of bacteria called cyanobacteria, is associated with ALS risk. did.
The review notes that exposure to formaldehyde and heavy metals such as mercury and manganese may also increase ALS risk.
Head trauma can damage the central nervous system, including the brain and spinal cord. Experiencing a head injury may increase your risk for ALS.
A 2021 meta-analysis found an association between head injury and ALS risk. The risk was higher for people with severe head injuries.
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A 2019 study linked higher-than-normal exposure to electric shocks and very low-frequency magnetic fields to a higher risk of ALS.
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Some research has linked excessive exercise to an increased risk of ALS. for example,
Research has linked several medical conditions to ALS risk.There are some
Some medical conditions are associated with decreased prevalence of ALS. for example,
Currently, there is no known way to prevent ALS.
However, addressing underlying ALS risk factors may reduce your risk. This includes quitting smoking and avoiding exposure to pesticides and heavy metals.
There is little evidence regarding diet and ALS. However, when you go on a diet,
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Other strategies that may not only be beneficial to your overall health, but may also help reduce your ALS risk.
The cause of ALS is unknown. For some people, ALS is familial and is caused by a specific genetic mutation.
Gender and race also influence the risk of ALS, with men and white people at higher risk. Other potential risk factors for ALS include exposure to environmental toxins, head trauma, and electric shock.
There is currently no way to prevent ALS. If you smoke, quitting and reducing your exposure to environmental toxins may reduce your risk. Healthy lifestyle choices such as diet, exercise, and stress reduction may also be beneficial.